Humans Who Have Restless Leg Syndrome
Requip is a treatment for

Parkinson’s Disease:
The precise mechanism of action of REQUIP as a treatment for Parkinson’s
disease is unknown, although it is believed to be due to stimulation of postsynaptic dopamine D2-type
receptors within the caudate-putamen in the brain. This conclusion is supported by studies that show
that ropinirole improves motor function in various animal models of Parkinson’s disease. In particular,
ropinirole attenuates the motor deficits induced by lesioning the ascending nigrostriatal
dopaminergic pathway with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in
primates. The relevance of D3 receptor binding in Parkinson’s disease is unknown.

Restless Legs Syndrome (RLS): The precise mechanism of action of REQUIP as a treatment for
Restless Legs Syndrome (also known as Ekbom Syndrome) is unknown. Although the pathophysiology
of RLS is largely unknown, neuropharmacological evidence suggests primary dopaminergic system
involvement. Positron emission tomographic (PET) studies suggest that a mild striatal presynaptic
dopaminergic dysfunction may be involved in the pathogenesis of RLS.
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