Simulated Neurons

Science 3 July 2009:
Vol. 325. no. 5936, pp. 87 - 89
DOI: 10.1126/science.1170869
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Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory
Manuel F. López-Aranda,1,2,4 Juan F. López-Téllez,1,2,4 Irene Navarro-Lobato,1 Mariam
Masmudi-Martín,1 Antonia Gutiérrez,3,4 Zafar U. Khan1,2,4,*

Cellular responses in the V2 secondary visual cortex to simple as well as complex visual
stimuli have been well studied. However, the role of area V2 in visual memory remains
unexplored. We found that layer 6 neurons of V2 are crucial for the processing of object-
recognition memory (ORM). Using the protein regulator of G protein signaling–14 (RGS-14) as
a tool, we found that the expression of this protein into layer 6 neurons of rat-brain area V2
promoted the conversion of a normal short-term ORM that normally lasts for 45 minutes into
long-term memory detectable even after many months. Furthermore, elimination of the same-
layer neurons by means of injection of a selective cytotoxin resulted in the complete loss of
normal as well as protein-mediated enhanced ORM.